This study was carried out to assess the antibacterial activity of selected medicated soaps against bacteria associated with wound infections. Wound swab samples were collected from patients with infected wounds and analyzed using standard microbiological techniques. Bacteria isolated and identified from the samples included Staphylococcus aureus, Pseudomonas spp., and Bacillus spp. Five brands of medicated soaps Carex, Tura, Dettol, Septol, and Tetmosol were evaluated for their antibacterial activity using the agar well diffusion method on Mueller-Hinton agar. The results revealed varying degrees of antibacterial effectiveness among the tested soaps. Septol and Dettol exhibited the highest zones of inhibition against all the identified bacteria, indicating strong antibacterial potency. Carex showed moderate activity, while Tura and Tetmosol demonstrated the least inhibitory effects. Staphylococcus aureus was found to be the most susceptible organism to the medicated soaps, whereas Pseudomonas spp. showed the highest resistance. The findings of this study suggest that Septol and Dettol are the most effective medicated soaps for inhibiting bacterial pathogens commonly associated with wound infections. It is therefore recommended that individuals should use medicated soaps with proven antimicrobial properties for personal hygiene, especially in preventing wound infections. Further research should be carried out to identify the specific active ingredients responsible for the antibacterial effects and to test their efficacy against a wider range of clinical isolates.