Evaluation of the effect of some medicinal plants against quorum sensing regulated virulence factors in Pseudomonas aeruginosa

2021, Vol. 3, Issue 2

Evaluation of the effect of some medicinal plants against quorum sensing regulated virulence factors in Pseudomonas aeruginosa

authors
Nwanekwu Ken, Obiukwu C E, Anumihe O C

abstract
The effect of some commonly used medicinal plants in Southeast Nigeria namely Carica papaya, Psidium gujava and Citrus cinensis against quorum sensing regulated virulence factor such as twitching motility, pyocyanin production, proteolytic activity and cell adhesion in Pseudomonas aeruginosa was evaluated in this study using spectrophotometric methods. Result showed that Carica papaya and Psidium gujava plant extract revealed complete inhibition of Pseudomonas aeruginosa for twitching motility. Carica papaya plant extract showed greater inhibition on cell adhesion and proteolytic activity while the inhibition of pyocyanin production was lowest in Citrus cinensis and highest in Carica papaya. Overall, the plant extract showed variable effects with Carica papaya plant extract showing the best effect against quorum sensing regulated virulence factors in Pseudomonas aeruginosa. This study shows the potential use of these plant extracts in the treatment of microbial infections by inhibiting bacterial virulent factors and it's associated antibiotics resistance capabilities.

Download | Pages : 56-60

How to cite this article:

Nwanekwu Ken, Obiukwu C E, Anumihe O C. Evaluation of the effect of some medicinal plants against quorum sensing regulated virulence factors in Pseudomonas aeruginosa. International Journal of Biotechnology and Microbiology, Volume 3, Issue 2, 2021, Pages 56-60